PhD student position in in Cell and Molecular biology / Immunology

Malmö

Ref REK2021/61

About Malmö University

Malmö University is an innovative, urban and international institute of higher education, located in the centre of Malmö. We have around 1,800 employees and 24,000 students. Our research and education are characterised by the role we believe a university should play in an open society — to contribute to sustainability and equality in a scientifically grounded way with external partners and stakeholders. Identifying and addressing the challenges of the future are of highest priority. Our researchers and students work collaboratively to create, share and spread knowledge in order to understand, explain and develop society — both locally and globally.

Faculty

The Department of Biomedical Science offers a programme leading to a professional qualification, Biomedical Scientist (first cycle, 180 credits), and a Masters' programme, Biomedical Surface Science (second cycle, 120 credits), as well as first and second cycle freestanding courses. The Department negotiates the multifaceted intersection between biology, chemistry, medicine, physics, and technology and the interdisciplinary approach to research and education aims to further develop the theoretical and practical understanding of the complex subject matter. Drawing on the balance between basic and applied research, the Department has been successful in attracting funding from regional, national, and international research funding bodies. In addition, in the pursuit of possible applications, several industry funded contract research projects are currently running at the Department.

The research at the faculty is also linked to the research center Biofilms - Research Center for Biointerfaces, which combines biomedical science with clinical and translational research in medical, dental, food and environmental application areas in close collaboration with regional industry.

Department

The Department of Biomedical Science offers a programme leading to a professional qualification, Biomedical Scientist (first cycle, 180 credits), and a Masters' programme, Biomedical Surface Science (second cycle, 120 credits), as well as first and second cycle freestanding courses. The Department negotiates the multifaceted intersection between biology, chemistry, medicine, physics, and technology and the interdisciplinary approach to research and education aims to further develop the theoretical and practical understanding of the complex subject matter. Drawing on the balance between basic and applied research, the Department has been successful in attracting funding from regional, national, and international research funding bodies. In addition, in the pursuit of possible applications, several industry funded contract research projects are currently running at the Department.

The research at the faculty is also linked to the research center Biofilms - Research Center for Biointerfaces, which combines biomedical science with clinical and translational research in medical, dental, food and environmental application areas in close collaboration with regional industry.

About the position

The research activities will be conducted in a network of academic, industrial, and clinical partners within a larger project entitled Biobarriers - Health, Disorders and Healing. The general vision of the research project is to improve health and healing of biological barriers by modernizing clinical treatments and products based on molecular level knowledge. In particular, the aim of the current PhD-project is to develop advanced ex vivo cell- and tissue models for enabling/enhancing animal-free studies of healthy and disordered skin. Usually, therapeutic targets of biological barriers, e.g., skin, are tested in vitro including cell-based assays. These models usually do not grasp the holistic biological barrier complexity. Thus, there is an increasing interest to develop and use advanced skin models before any testing is started on animals or humans. Excised human or animal skin have traditionally been used as models. Though animal skin is easily available as byproduct from food industry, it differs from human skin. Thus, there is a need for functional ex vivo human skin models for evaluation of molecular treatment mechanisms, as well as assessment of efficacy and safety. Human skin equivalent can be designed as epidermis only, dermis only, or full thickness depending on the application. Currently there are several commercially available ex vivo skin models for making controlled tests. However, new treatments and growing understanding of the complexity of human skin require broader variety and deeper understanding of ex vivo skin models. Studies that include microbial components onto skin models are rare. The host-microbe interaction between keratinocytes and microbiota could be a key factor for achieving the skin barrier function observed in native skin. Studies on the effects of complete microbiomes on stratum corneum formation, composition and permeability or the keratinocyte interaction with immune cells are pivotal but still missing. The main goal is to establish skin cell culture models of dermal fibroblasts, keratinocytes, melanocytes and immune cells as well as cultures of cells from human skin biopsies ex vivo.

Apart from carrying out research within these areas the applicant is expected to take responsibility for the maintenance of the instruments involved and to be active by supervising graduate and postgraduate students and fellow scientists in the techniques and participate in teaching at graduate and postgraduate levels.

PhD-student position in Biomedical Science

The PhD student will be admitted to a PhD education at Malmö University. The PhD education will run for four years on 100% working time. The research topic is "Biomedical Science" and the Faculty offers a Degree of Doctor of Philosophy in Medical Science. Provisions on appointment as a PhD student are laid out in the Swedish Higher Education Ordinance, Chapter 5. When making the appointment, under Chapter 5, Section 5 of the Swedish Higher Education Ordinance, consideration must be given to the student's ability to benefit from studies.

In order to be considered for admission as a doctoral student, the applicant must meet the general and specific entry requirements for third-cycle courses and study programmes, and be considered in other respects to have the ability required to benefit from the course or study programme. The higher education institution may permit an exemption from the general entry requirements for an individual applicant, if there are special grounds. Ordinance (2010: 1064).

General entry requirements:

  1. a second-cycle higher education degree
  2. completed course requirements of at least 240 higher education credits, of which at least 60 higher education credits are second-cycle, or having in some other way, nationally or internationally, acquired equivalent knowledge.

Specific entry requirements:

  1. comprise at least 90 ECTS, of which 30 ECTS should be at second cycle level, in a subject which is of relevance for the research domain in question or which in some other way involve broadly equivalent knowledge.

Basis of assessment

The ideal candidate has a background in biomedical laboratory science, cell biology, molecular biology, biomedicine, immunology, or related disciplines. Good communication skills in English (written and spoken) are necessary, and adequate knowledge in Swedish is considered a strong merit. Hands-on experience in in vitro cell culture is a further strong merit. Hands-on experience in some of the following methods is highly valued: cell-based assays, ELISA, flow cytometry, immunohistochemistry, immunofluorescence, qPCR and histological techniques. In addition to formal competence, University employees must possess the personal capacities necessary to perform the duties of the position well and to represent the University in the best possible way. The successful candidate should have the ability to work in a team and collaborate with people in complementary disciplines.

Further information

Dr. Anna Gustafsson, +46 (0)40 6657416, anna.gustafsson@mau.se
Dr. Lars Ohlsson, 040-6657497, lars.ohlsson@mau.se
Prof. Tautgirdas Ruzgas +46 (0)40 6657431, tautgirdas.ruzgas@mau.se
For general questions regarding employment at Malmö university, contact HR-specialist Jill Moberger +46 (0)40 6657840, jill.moberger@mau.se

In our recruitment work, Malmö University has taken a stand regarding recruitment channels and marketing. We therefore decline all offers of advertising and recruitment assistance in connection with this advertisement.

Application

You may apply for this position via Malmö University's recruitment system by clicking on the "Apply" button. As an applicant, you are responsible for ensuring that your application is completed in accordance with the advertisement, and that it is provided to the University no later than 30th  of April 2021.The applicant is responsible for ensuring that the University can read what is written in the application. If the application is not written in Swedish, English or any of the Nordic languages, the applicant is responsible for the application and its appendices being translated.

The application must include:

  • Signed list of qualifications (Curriculum vitae)
  • A brief summary of scientific, teaching and other qualifications relevant to the position, together with a motivation for applying to this PhD-student position
  • Diplomas, transcript of records and other certificates relevant for the position
  • Attest copies of certificates
  • List of potential scientific publications
  • Copy of a master/magister degree thesis or equivalent
  • References (at least two; names, titles, contact information positions/relation)

Miscellaneous

The post is full-time and for a limited period, in accordance with the Higher Education Ordinance Chapter 5 Section 7

Malmö University is a workplace and higher education institution that is characterised by an open and inclusive approach, where gender equality and equal terms add value to our activities.

Start date

As soon as possible

Union representatives

SACO-S: Desirée Annvir, desiree.annvir@mau.se
Lärarförbundet: Carl-Erik Blomberg, carl-erik.blomberg@mau.se
ST/OFR: Aje Carlbom aje.carlbom@mau.se

We are looking forward to receiving your application!

 


Du ansöker senast 2021-04-30 genom att klicka på knappen nedan.