at the Department of Molecular Biosciences, The Wenner-Grens Institute. Closing date: 15 August 2021.

The Department of Molecular Biosciences, Wenner-Gren Institute (MBW) conducts experimental basic research in molecular cell biology, intergrative biology and infection and immune biology. The research environment is characterized by a modern and advanced methodology and has a strong international profile. MBW is one of the larger departments of the Faculty of Science at Stockholm University with more than 30 research groups and about 180 employees, of whom 65 are doctoral students. Read more about MBW at www.su.se/mbw.

Project description
The aim of the project is to improve our understanding of the molecular processes involved in radiotherapy-induced carcinogenesis occurring as a late consequence among childhood cancer survivors. Genetic and epigenetic changes representing signs of radiation-induced carcinogenesis will be studied in normal cells exposed to fractionated radiation (simulating radiotherapy). Specifically, the project aims at studying: 1) Mechanistic analysis of radiotherapy-related carcinogenesis based on risk alleles (SNPs); 2) Epigenetic modifications as a result of fractionated radiation exposure of normal cells; 3) The role of environmental factors in this process. Additionally, the candidate will be involved in another project exploring individual differences in normal tissue response concerning early and late radiotherapy-induced side effects such as skin reactions.

Main responsibilities
The position involves application of cell culture and molecular biology techniques to analyse DNA damage, cell death and genetic and epigenetic modifications induced by ionising radiation. All exposure facilities are installed at Stockholm University. The candidate will also participate in other related projects running in the group.

Qualification requirements
Postdoctoral positions are appointed primarily for purposes of research. Applicants are expected to hold a Swedish doctoral degree or an equivalent degree from another country. 

Assessment criteria
The degree should have been completed no more than three years before the deadline for applications. An older degree may be acceptable under special circumstances, which may involve sick leave, parental leave, clinical attachment, elected positions in trade unions, or similar.

In the appointment process, special attention will be given to research skills. Doctoral degree in the field of radiation biology, molecular or cell biology, cancer biology, or similar areas is a suitable background. Experience with techniques to culture cells, perform siRNA and CRISPR/Cas9 knockdown/knockout, analyse epigenetic modifications, measure DNA damage and repair as well as to assay cell death is regarded as an asset. Additional merits include the use of methods such as real time qPCR, Western blot, fluorescence microscopy, flow cytometry and SNP analysis.

Terms of employment
The position involves full-time employment for a maximum of two years, with the possibility of extension under special circumstances. Start date 2021-10-01 or as per agreement.

Stockholm University strives to be a workplace free from discrimination and with equal opportunities for all.

Contact
Further information about the position can be obtained from Dr. Lovisa Lundholm, telephone: +46 8 16 41 40, lovisa.lundholm@su.se, Professor Andrzej Wojcik, telephone: +46 8 16 12 17, andrzej.wojcik@su.se.

Union representatives
Ingrid Lander (Saco-S), telephone: +46 708 16 26 64, saco@saco.su.se, Alejandra Pizarro Carrasco (Fackförbundet ST/Lärarförbundet), telephone: +46 8 16 34 89, alejandra@st.su.se, and seko@seko.su.se (SEKO).

Application
Apply for the position at Stockholm University's recruitment system. It is the responsibility of the applicant to ensure that the application is complete in accordance with the instructions in the job advertisement, and that it is submitted before the deadline.

Please include the following information with your application

  • Your contact details and personal data
  • Your highest degree
  • Your language skills
  • Contact details for 2–3 references

and, in addition, please include the following documents

  • CV – degrees and other completed courses, work experience and a list of publications
  • Cover letter describing:
    – why you are interested in the field/project described in the advertisement
    – what makes you suitable for the project in question
  • Copy of PhD diploma
  • Letters of recommendation (no more than 3 files)
  • Publications in support of your application (no more than 3 files).

The instructions for applicants are available at: How to apply for a position.

You are welcome to apply!

Stockholm University contributes to the development of sustainable democratic society through knowledge, enlightenment and the pursuit of truth.

Closing date: 15/08/2021