Ref PAR 2022/1700
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At the Department of Rheumatology and Inflammation Research, at the Institute of Medicine, the main research areas are inflammation and inflammatory diseases irrespective of whether they are caused by allergies, infections or are autoimmune diseases. The aim is to investigate the underpinning mechanisms behind the inflammation. Several of our researchers also work as senior consultants at the clinics at Sahlgrenska University Hospital, which is a great advantage especially for translational research.
The goal of group is to understand how inflammatory processes regulates and what role the so-called G protein-coupled receptors has in the regulation, when it works well and when the balance is disrupted which leads to inflammatory disease situation.
The cells will be isolated from healthy human blood donors and patients with inflammatory diseases as well as CRISPR/Cas9 engineered neutrophils. Basic cell biological/biochemical/receptor pharmacological techniques will be used to study regulatory mechanisms and function of naive as well as CRISPR/Cas9 engineered neutrophils. At the signal level, these methods include HTRF-based cAMP assay, different G protein subtype activation, β-arrestin translocation and cytosolic calcium changes. The neutrophil functions of importance include migration (chemotaxis), phagocytosis, endocytosis, granule secretion and activation of the NADPH-enzyme system both at the cell membrane and granule membrane to produce free oxygen radicals. In addition, the work will involve cell culture, Western blot, flow cytometry, cell imaging and subcellular fractionation.
The applicant is required to hold a PhD and have postdoc training experience in the field of G protein coupled receptor signaling, neutrophil pathophysiology and auto/inflammatory disease. The applicant should also have extensive hands-on experience in working with neutrophils from healthy donors and patients suffering from rheumatic diseases. Extensive knowledge of methods to study neutrophils, G protein coupled receptor signaling and the production and role of reactive oxygen species generated in different cellular compartments is required. A postdoc experience abroad in the field of rheumatic diseases is an advantage. In addition, good track record in teaching, supervising bachelor/master/PhD students, and collaborating with national/international scientists from different disciplines is an advantage. Good speaking and writing skills in English and Swedish are required. We value personal qualities highly and great emphasis will be placed on personal suitability to the group.
Type of employment: Permanent, an initial probationary employment of 6 months may be applied Extent: 100 % Location: Institute of Medicine, Gothenburg First day of employment: According to agreement.
Contact information for the post
Huamei Forsman, Adjunct Professor, +46(0)70-8701899, firstname.lastname@example.org
Lill Mårtensson-Bopp, Head of Department, +46(0)31-3422492, email@example.com
Union representatives at the University of Gothenburg can be found here: https://www.gu.se/om-universitetet/jobba-hos-oss/hjalp-for-sokande
Information for International Applicants
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Certificate of PhD degree must be attached to the application.
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Applications must be received by: 2022-12-27.
The University works actively to achieve a working environment with equal conditions, and values the qualities that diversity brings to its operations.
Salaries are set individually at the University.
In accordance with the National Archives of Sweden’s regulations, the University must archive application documents for two years after the appointment is filled. If you request that your documents are returned, they will be returned to you once the two years have passed. Otherwise, they will be destroyed.
In connection to this recruitment, we have already decided which recruitment channels we should use. We therefore decline further contact with vendors, recruitment and staffing companies.