Postdoctor in Molecular Neurobiology, 2 positions

Ref PAR 2022/1518

The University of Gothenburg tackles society’s challenges with diverse knowledge. 56 000 students and 6 600 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract scientists and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.

The Department of Chemistry and Molecular Biology conducts high-quality research and education in chemical sciences and molecular life sciences. Our research and education focuses on a deep understanding of chemical and biological processes in cells and in the environment.

We address important societal issues such as antibiotic resistance, cancer, brain diseases, environmental problems and climate change. In this way, we contribute to achieving the UN's global goals for sustainable development in the areas of good health and well-being, sustainable energy for all, sustainable cities and communities, and combating climate change.

The department is an international environment with interdisciplinary collaborations in both research and education, and contributes strongly to the University of Gothenburg's top ranking in life science. The Department of Chemistry and Molecular Biology has around 200 employees. We are located in central premises both on Campus Johanneberg and on Campus Medicinareberget in Gothenburg.

The current project will investigate a class of protein in the family of ligand-gated ion channels. These proteins are receptors that are involved in fast neurotransmission in nervous systems, they also have an important role in synaptic plasticity. The Morud Lekholm group use the nematode C. elegans to study these receptors and how they are involved in regulating and controlling different forms of behaviors, such as learning and escape behaviors. The project aims to investigate the basic principles of these receptors by characterizing their basic functions, such as how they are recruited into synapses upon learning events and how a dysfunctional synapse inclusion influences the learning ability. Moreover, the project will, by utilizing biophysical techniques, study how the structural perturbations depend on the identity of the activating ligand, and how this in turns influence the effect size produced by the ion channel. The projects also include molecular biology work for generating new transgenic C. elegans lines and for the production of baculoviruses to be used for protein production in Spodoptera frugiperda Sf9 cells.

Duties 

The position includes the following tasks: to independently plan and execute the experimental lab work and data analysis. The candidate is also expected to express and purify protein in Sf9 cells, prepare protein for cryo-EM and difference liquid SAXS experiments, produce new transgenic C. elegans and baculovirus lines, identify protein binding partners to ligand-gated ion channels, design and set up new assays for tracking of C. elegans behaviors and perform super resolution microscopy in GFP-tagged C. elegans. The postdoc shall also, in collaboration with other group members, produce scientific papers, analyze data to be able to present these findings at international conferences.

Qualifications 

Requirements for the position are:

  • To qualify for the postion the applicant must have completed a Swedish Doctoral degree or must have a foreign degree corresponding to a Swedish Doctoral degree preferably in neurobiology, molecular biology, biochemistry or structural biology. The Doctoral degree must be finished at the timepoint of employment decision.
  • Excellent communicative skills are required, including fluency in oral and written English since our department is a very international environment.

Meritorious for the position are:

  • Previous experience working with C. elegans is an important merit, as well as previous experience with in vivo characterization of previously uncharacterized proteins in C. elegans using genetic or electrophysiological techniques, or methods such as advanced light microscopy and molecular biological techniques such as gene editing using CRISPR/Cas9.
  • We seek a motivated and ambitious person with documented experience of producing and analyzing large datasets.
  • Good knowledge of biochemical methods, molecular biology and analysis of SAXS and cryo-EM datasets are meriting.
  • The candidate is expected to have several published articles in well-known journals. 

Employment 

Fixed term during two years full time (100%) at the Department of Chemistry and Molecular Biology. 

Contact information for the post 

If you have any questions about the position, please contact associate senior lecturer Julia Morud Lekholm, 031-786 3237, julia.morud@gu.se.

Unions 

Union representatives at the University of Gothenburg can be found here: https://www.gu.se/om-universitetet/jobba-hos-oss/hjalp-for-sokande 

Application 

Submit your application via the University of Gothenburg’s recruitment portal by clicking the “Apply” button. It is your responsibility to ensure that the application is complete as per the vacancy notice, and that the University receives it by the final application deadline. 

Your application must include:

  • A cover letter with the applicant’s justification for the application, i.e., that describes how the applicant meets the selection criteria.
  • A list of qualifications (CV).
  • Certificate of PhD exam and other educations of relevance.
  • Complete list of publications, including submitted and accepted manuscripts.
  • Employments certificates and other documents deemed important by the applicant.

Applications must be received by: 2022-12-07

The University works actively to achieve a working environment with equal conditions, and values the qualities that diversity brings to its operations.

Salaries are set individually at the University.

In accordance with the National Archives of Sweden’s regulations, the University must archive application documents for two years after the appointment is filled. If you request that your documents are returned, they will be returned to you once the two years have passed. Otherwise, they will be destroyed.

In connection to this recruitment, we have already decided which recruitment channels we should use. We therefore decline further contact with vendors, recruitment and staffing companies.