Postdoctor in Biochemistry

Ref PAR 2022/1557

The University of Gothenburg tackles society’s challenges with diverse knowledge. 56 000 students and 6 600 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract scientists and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.

The Department of Molecular and Clinical Medicine, at the Institute of Medicine, conducts translational research primarily on metabolism, diabetes, obesity and cardiovascular disease in order to improve health and healthcare in the community. The overall goal is to create an excellent translational research environment of a very high international standard.

The normal gut microbiota constitute up to 90% of the cells in our body. By combining clinical material and gnotobiotic animal models we have demonstrated that the gut microbiota may affect our physiology and metabolism. Our working hypothesis is that the gut microbiota affects our physiology through metabolites that are produced by the bacteria. We are now recruiting a postdoctoral fellow to investigate activity and function in microbial enzymes and also participate in the development of specific inhibitors for these enzymes.

Subject area 

Microbiota and metabolism.

Subject area description 

The gut microbiota contains 1000-fold more genes than our own genome. Several of these microbial genes encode enzymes that can produce bioactive metabolites. Even if we just started to scratch the surface it has begun to be obvious that several of these metabolites may have profound effect on our physiology and metabolism. For example, they can increase or decrease insulin sensitivity and other metabolic phenotypes.

Duties 

Identify microbial enzymes and novel activities through modeling. Thereafter determine substrate specificity and enzyme activity by using bacterial lysates as well as purified proteins. The applicant will also further characterize the enzyme functions, for example identifying cofactors, as well as identify the cellular localization. Potentially the applicant will also crystalize the enzyme for structural determination. Some development of enzyme activity may be performed.

Eligibility

To qualify as a postdoctoral researcher the applicant should hold a PhD in a relevant subject. Since postdoctoral constitutes a qualifying appointment for junior researchers, we aim to target those who have a doctoral degree not older than 3 years.

Assessment criteria 

Strong background in enzyme chemistry is a requirement. Experience of structural determination of proteins, especially enzymes, as well as modelling of protein structures and development of enzyme inhibitors are strong merits. Knowledge in bioinformatics as well as industrial and/or international experience are merits. It is essential that the applicant is creative, can work independent, but also interact with other researchers and clinicians within a greater team, and great emphasis will be placed on personal suitability. Knowledge in English, in both writing and verbally, are requirements.

Employment 

Type of employment: Fixed-term employment, 36 months Extent: 100 % Location: Institute of Medicine, Gothenburg First day of employment: As soon as possible or according to agreement.

Contact information 

Fredrik Bäckhed, Professor, +46(0)70-2182355, Fredrik.Backhed@wlab.gu.se

Malin Levin, Head of Department, Malin.Levin@wlab.gu.se

Unions 

Union representatives at the University of Gothenburg can be found here: https://www.gu.se/om-universitetet/jobba-hos-oss/hjalp-for-sokande 

Information for International Applicants

Visit the webpage Join us - jobs and career for more information on the Institute of Medicine and what opportunities we have for you. Discover our world-class research and research infrastructure, as well as what the benefits are for you and your family.

Application 

Please attach PhD certificate with the application, if the PhD certificate has not yet been issued, it needs to be attached latest at the time when the employment decision is to be made.

Submit your application via the University of Gothenburg’s recruitment portal by clicking the “Apply” button. It is your responsibility to ensure that the application is complete as per the vacancy notice, and that the University receives it by the final application deadline.  

Applications must be received by: 2022-12-01

The University works actively to achieve a working environment with equal conditions, and values the qualities that diversity brings to its operations.

Salaries are set individually at the University.

In accordance with the National Archives of Sweden’s regulations, the University must archive application documents for two years after the appointment is filled. If you request that your documents are returned, they will be returned to you once the two years have passed. Otherwise, they will be destroyed.

In connection to this recruitment, we have already decided which recruitment channels we should use. We therefore decline further contact with vendors, recruitment and staffing companies.