Postdoctor in experimental diabetes research

Ref PAR 2022/1474

The University of Gothenburg tackles society’s challenges with diverse knowledge. 56 000 students and 6 600 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract scientists and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.

The Institute of Neuroscience and Physiology at the Sahlgrenska Academy, Department of Physiology, is seeking a talented postdoctoral fellow for an ERC-supported project at the international forefront.

You will investigate the molecular mechanisms underlying type 2 diabetes with the long-term goal of finding new anti-diabetic treatments.

As a postdoc, you will have the support of Prof. Anders Rosengren as well as an extensive network within the Wallenberg Centre for Molecular and Translational Medicine, which involves world-leading scientists at four Swedish universities, AstraZeneca and SciLifeLab, which will provide you with the guidance and knowledge you need to develop your career. You will get the opportunity to present at international scientific conferences and publish high-profile papers. The project is supported by an ERC Consolidator project as well as by Knut and Alice Wallenberg Foundation.

Subject area

Experimental diabetes research

Subject area description

 The molecular mechanisms underlying type 2 diabetes.

Job assignments

The project is truly translational and you will use human pancreatic islets as the starting point to identify the physiological and gene expression changes that contribute to defective insulin secretion in type 2 diabetes. Interesting observations have shown that there are pools of beta-cells with different phenotype and functional capacity within an islet. Intriguingly, it has recently been demonstrated that the proportion of such pools is altered in type 2 diabetes. By defining the phenotype and proportion of cellular pools in diabetic and non-diabetic conditions in a more precise manner than has previously been possible, the project has the potential to considerably improve our understanding of beta-cell failure and its reversal. It may also lead to the identification of new targets that can be exploited for beta-cell preservation, which is one of the main goals of diabetes research and an urgent clinical need.

As postdoctor, you will use a range of cell-physiological and cell-biological techniques as well as qPCR and transfection systems. In addition to the physiological studies, you will work closely with experts on single-cell RNA sequencing to study the associated gene expression changes. The ability to couple single-cell gene expression with functional data is an exciting area that hasn't been explored to its full potential, making this an opportunity to make a real difference to the future of medical science.

The translational profile of our team means that you will also be able to work with clinical researchers to test and validate the disease relevance of your experimental findings as we have previously done in e.g. Rosengren AH et al., Science 2010, Tang Y et al., Science Translational Medicine 2014 and Axelsson AS et al., Science Translational Medicine 2017.

Eligibility

To qualify as a postdoctoral researcher the applicant should hold a PhD in a relevant subject. Since postdoctoral constitutes a qualifying appointment for junior researchers, we aim to target those who have a doctoral degree not older than 3 years from the application deadline.

Assessment

The applicant for employment must have a PhD degree and is expected to have a strong record of scientific productivity with publications as first author in internationally renowned journals.

The candidate must also have extensive experimental background in cell physiology and/or gene expression studies. Previous research in the diabetes area is beneficial but not required. Strong scientific work ethics and commitment to develop yourself as a scientist will be important evaluation criteria. 

The applicant is expected to plan, execute, and analyze experiments in an independent manner and to actively contribute scientifically to the group. The suitable person must have excellent oral and written communication skills in English and be an excellent team player. Great emphasis will be placed on personal suitability.

Employment

The employment is limited (temporary) for 2 years, 100% of full-time, and is placed at the Institute of Neuroscience and Physiology. Starting date: as soon as possible or as agreed. 

Contact information 

If you have questions regarding the employment please contact Professor Anders Rosengren, phone: +46 705 31 67 04, e-mail: anders.rosengren@gu.se

Manager in charge is Senior Lecturer/Head of Department Lars-Gunnar Pettersson, phone: +46 31 786 35 07, e-mail: lars-gunnar.pettersson@gu.se

Application documents are not to be submitted through the contact persons.

Unions

Union representatives at the University of Gothenburg can be found here: https://www.gu.se/en/work-at-the-university-of-gothenburg/how-to-apply

Application

Submit your application via the University of Gothenburg’s recruitment portal by clicking the “Apply” button. 

Please enclose PhD certificate with the application.

Applications must be received by: 2022-12-06

 

Information for International Applicants 

Choosing a career in a foreign country is a big step. Thus, to give you a general idea of what we and Gothenburg have to offer in terms of benefits and life in general for you and your family/spouse/partner please visit: 

https://www.gu.se/en/about-the-university/welcome-services 
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The University works actively to achieve a working environment with equal conditions, and values the qualities that diversity brings to its operations.

Salaries are set individually at the University.

In accordance with the National Archives of Sweden’s regulations, the University must archive application documents for two years after the appointment is filled. If you request that your documents are returned, they will be returned to you once the two years have passed. Otherwise, they will be destroyed.

In connection to this recruitment, we have already decided which recruitment channels we should use. We therefore decline further contact with vendors, recruitment and staffing companies.