Postdoctoral fellow in Cryo EM-studies of mitochondrial DNA replication and transcription
Ref PAR 2022/975
The University of Gothenburg tackles society’s challenges with diverse knowledge. 56 000 students and 6 600 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract scientists and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.
The Institute of Biomedicine is involved in both research and education. In both of these areas, we focus on fundamental knowledge of the living cell – what it consists of, how it works, how its function is directed by the genetic material, and how it interacts with various kinds of micro-organisms. Using this knowledge, we try to elucidate the causes of diseases, and find new ways to diagnose and treat them.
The Institute is composed of the following four departments:
- The Department of Infectious Diseases
- The Department of Microbiology and Immunology
- The Department of Medical Biochemistry and Cell Biology
- The Department of Laboratory Medicine
At present, the institute has about 360 employees and approximately 450 million SEK in total assets
Cryo EM-studies of mitochondrial DNA replication and transcription
Subject area description
Mitochondria contain their own genome that codes for several subunits of the oxidative phosphorylation machinery. We have developed in vivo and in vitro techniques to study the basic mechanisms of human mitochondrial DNA replication and transcription, and how these processes are regulated.
In this project the candidate will study the structure of the mitochondrial replisome using cryo EM. The project will also involve studies of disease-causing mutations and their structural consequences. More information about the research group and our work can be found on the following web-page: www.falkenberglab.org
The eligibility criteria for employing teaching staff are set out in Chapter 4 of the Higher Education Ordinance and in the Appointment Procedure for Teaching Posts at the University of Gothenburg.
To be eligible for appointment as a postdoc, the applicant is required to have a doctoral degree, a doctoral degree in art or a foreign degree that is deemed to be equivalent to a doctoral degree. This eligibility requirement must be met before the employment decision is made.
In the first instance, those who have completed their degree no more than three years prior to the end of the application period shall be considered. Those who have completed their degree more than three years prior to the end of the application period may also be considered in the first instance if special grounds exist. Special grounds relate to leave of absence due to illness, parental leave, commissions of trust within union organisations, service within the defence services or other similar circumstances, as well as clinical service or service/assignment relevant to the subject area.
We are looking for a highly motivated individual with significant experience in cryo EM and/or structural biology. Knowledge of mitochondrial systems and documented experience with cloning, mutagenesis, gene expression, cell culture, radiolabeled isotopes, and in vitro DNA replication and/or transcription are of merit. The work will involve collaboration both within and outside the group, and so good teamwork and communication skills are important. The candidate is expected to be enthusiastic, capable of planning and executing research independently, and to have a passion and curiosity for science. Fluent written and spoken English is required since we operate in a very international environment.
Regulations for the evaluation of qualifications for academic positions are given in Chapter 4, Section 3 - 4 of the Higher Education Ordinance.
The employment is full time and temporary, two years with the possibility of one year's extension, with placement at the Institute of Biomedicine. First day of employment as agreed.
If you have any questions about the position, please contact Maria Falkenberg, Professor, +46 (0)317863444, firstname.lastname@example.org
Union representatives at the University of Gothenburg can be found here: https://www.gu.se/om-universitetet/jobba-hos-oss/hjalp-for-sokande
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The application should contain:
- A cover letter giving a brief description of previous research experience, and a motivation to why you are applying
- A detailed CV including a list of publications
- Proof of completed PhD
- Contact details of two references.
Applications must be received by: 2022-07-19
Information for International Applicants
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