Postdoctoral researcher in Porous drug carrier platform for inhalation therapy

Malmo

Ref REK 2021/279

About Malmö University

Malmö University is an innovative, urban and international institute of higher education, located in the center of Malmö. We have around 1,800 employees and 24,000 students. Malmö University is organized into five faculties: Faculty of Health and Society, Culture and Society, Education and Society, Faculty of Odontology and Technology and Society.

The Department of Biomedical Science, Faculty of Health and Society, offers a programme leading to a professional qualification, Biomedical Scientist (first cycle, 180 credits), and a Masters' programme, Biomedical Surface Science (second cycle, 120 credits), as well as first and second cycle freestanding courses. The Department negotiates the multifaceted intersection between biology, chemistry, medicine, physics, and technology and the interdisciplinary approach to research and education aims to further the theoretical and practical understanding of the complex subject matter. Drawing on the balance between pure and applied research, the Department has been successful in attracting funding from regional, national, and international research funding bodies. 

The research at the faculty is also linked to the research center Biofilms - Research Center for Biointerfaces, which combines biomedical science with clinical and translational research in medical, dental, food and environmental application areas in close collaboration with regional industry. 

About the position

As never before in the current worldwide context, there is an urgent need of novel therapeutic solutions to fight dangerous and contagious lung infections. One of the therapeutic challenges is to deliver high amount of drugs at the infection site reducing toxic effects. Inhalation therapies are highly recommended but often the delivered drug amount to the lungs is not sufficient.

In this context, our idea is to design a novel drug delivery technology using porous silica particles to administer molecules safely and effectively to the lungs. An effective inhaled drug therapy requires an appropriate powder formulation together with a well-designed medical device. The project will be performed in collaboration with Nanologica AB (Södertälje), a nanotechnology company that develops mesoporous silica particles for applications in life science, and Iconovo AB (Medicon Village, Lund), a company that develops a full range of inhalation devices. We believe that the project will advance an innovative drug delivery technology towards clinical perspective and that this research will lead to new opportunities and recommendations for inhaled pharmaceutical formulations. 

The specific scientific objectives are to:

  • evaluate and optimize loading and release of active pharmaceutical in the particles employing different methodology;
  • together with industrial partners, design and characterize the final medical device comprising drug, carrier and powder inhaler.
  • understanding the relevance of the formulations in biological systems.

Apart from carrying out research within these areas the applicant is expected to take responsibility for the maintenance of the instruments involved and to be active by supervising graduate and postgraduate students and fellow scientists in the techniques and participate in teaching at graduate and postgraduate levels. The applicant will be expected to take part in applications for external funding to support research activities. 

Further, considering that the project requires collaboration between academic and industrial partners, it is expected that the applicant actively communicates and collaborates within this context; documented project management and leadership abilities are therefore valued.

Specific requirements for this position:  

Candidates must hold a PhD in physical chemistry, chemical engineering, nanotechnology, physical pharmacy, or a similar field.

The following would be of benefit for the position:

The ideal candidate has experience with surface and colloidal chemistry, porous particles and powder technology. Experience in inhalation formulations, drug carriers, formulation of biologics and particle engineering is considered a merit.

Hands-on experience in some of the following methods is highly valued:

  • Solid state analysis (DSC, ITC, isothermal microcalorimetry, TGA, FTIR),
  • SEM and AFM,
  • LC systems with spectrophotometry and/or mass spectroscopy detection,
  • Spray drying and freeze-drying technologies,
  • Aerodynamic particle size determination,
  • small- and wide-angle X-ray diffraction/scattering and other scattering techniques
  • cellular and bacterial cultures, air/liquid interface cells model, gene and proteins expression

 

Assessment criteria

  • The quality and focus of the doctoral thesis.
  • Research activities within fields relevant to the appointment in question.
  • Documented ability to independently conduct research of a sufficient standard.
  • Reflective presentation of their own pedagogical outlook and practices.
  • Demonstrated ability to communicate and collaborate with actors in other parts of society with a connection to education and research.

 

Further information

For more information contact:
Sabrina Valetti, +46 (0)703822786, sabrina.valetti@mau.se
For general questions regarding employment at Malmö university, contact HR-specialist Jill moberger +46 (0)40 6657840, jill.moberger@mau.se

In our recruitment work, Malmö University has taken a stand regarding recruitment channels and marketing. We therefore decline all offers of advertising and recruitment assistance in connection with this advertisement.

Application

You apply for this position via Malmö University's recruitment system by clicking on the "Apply" button. As an applicant, you are responsible for ensuring that your application is completed in accordance with the advertisement, and that it is provided to the University no later than January 23rd, 2022.

The educational qualifications may be documented with guidance from  Qualifications portfolio for lecturers/researchers at Malmö University  See also Appointment Rules at Malmö University. Books and any other documents, such as publications, that cannot be sent electronically should be sent in triplicate in an envelope marked with reference number REK 2021/279 and posted to the HR Department, Malmö University, 205 06 Malmö. If the documents weigh more than 2 kg, they should be sent to the delivery address: HR Department, Malmö University, Matrosgatan 1, 205 06 Malmö, marked with reference number REK 2021/279

Miscellaneous

One-year position (full-time), starting April 1st, 2022.

Malmö University is a workplace and higher education institution that is characterised by an open and inclusive approach, where gender equality and equal terms add value to our activities. Malmö University applies individual salary setting.

Union representatives

SACO-S: Ann-Mari Campbell, ann-mari.campbell@mau.se
Lärarförbundet: Carl-Erik Blomberg, carl-erik.blomberg@mau.se
ST/OFR: Aje Carlbom aje.carlbom@mau.se

 

We are looking forward to receiving your application!

 


You apply no later than 23/01/2022 by clicking the apply button.