The Department of Biology and Biological Engineering was founded January 1 2015, and started off with high ambitions. The aim was to grow and become a leading center of innovation by combining the latest research in life sciences with biochemistry. And the department got off to flying start. In its first year, the numbers for publication, citation and external funding have been excellent.

The department consists of four divisions, each conducting outstanding research in the areas of industrial biotechnology, systems biology, chemical biology and food science. The overall goal is to help build a sustainable society and improve human health.

Nearly 150 people from 20 countries are currently working at the department. The working environment is characterized by respect, cooperation, responsibility, creativity and job satisfaction.

The Department of Biology and Biological Engineering has summarized its mission in four points:
• To be an attractive environment for top-level researchers in biological engineering
• To deliver top-level research results and innovative solutions for use in a sustainable society
• To offer excellent education that develops creative engineers and scientists
• To be a major contributor to international visibility of Chalmers

Information about the project
This project will be carried out in a highly interdisciplinary environment at the interface between biological and medical sciences.

The aim of the project is to use a recently developed technique that identifies single damage sites to personalize cancer chemotherapy. It is well known that different patients respond differently to a specific dose of a cytotoxic drug. Still this is something that is difficult to know before a specific treatment is started. The goal of the project is to, from a simple blood sample, be able to say how sensitive a specific person is to a specific drug. This will be done by exposing the blood sample to the drug of interest and subsequently count the number of damages the drug has caused. This is done using a novel single DNA molecule technique where individual damage sites are fluorescently labeled and subsequently analyzed using fluorescence microscopy. The project is run in close collaboration with Prof. Ola Hammarsten at  Sahlgrenska University Hospital. The group of Hammarsten works on novel ways of personalizing chemtherapy by mesuring DNA damage in clinical samples exposed to cytotoxic drugs, meaning that we will have excellent access to clinically relevant samples.

Major responsibilities
The PhD will work with the development of analytical procedures to quantify DNA damage and also ways of isolating DNA from human cells. Experiments will be performed primarily using cell cultures and fluorescence microscopy.

Your major responsibilities are to pursue your own doctoral studies. You are expected to develop your own scientific concepts and communicate the results of your research verbally and in writing, both in Swedish and in English. The position generally also includes teaching on Chalmers' undergraduate level or performing other duties corresponding to 20 per cent of working hours.

Position summary
Full-time temporary employment. The position is limited to a maximum of five years.

The successful candidate should have a master's level degree corresponding to at least 240 higher education credits in biosciences, biophysics, bioengineering, analytical chemistry, or related disciplines. Expertise in cancer biology and/or micro/nanofluidics and in the design of bioanalytical assays would be a strong asset. Some basic knowledge in Matlab is also preferred.

The position requires sound verbal and written communication skills in English.

Chalmers continuously strives to be an attractive employer. Equality and diversity are substantial foundations in all activities at Chalmers.

Application procedure
The application should be marked with Ref 20180033 and written in English. The application should be sent electronically and be attached as pdf-files, as below:

CV: (Please name the document: CV, Family name, Ref. number)
• CV
• Other, for example previous employments or leadership qualifications and positions of trust.
• Two references that we can contact.

Personal letter: (Please name the document as: Personal letter, Family name, Ref. number)
• 1-3 pages where you introduce yourself and present your qualifications.
• Previous research fields and main research results.
• Future goals and research focus. Are there any specific projects and research issues you are primarily interested in?

Other documents:
• Copies of bachelor and/or master’s thesis.
• Attested copies and transcripts of completed education, grades and other certificates, eg. TOEFL test results.

Please use the button at the foot of the page to reach the application form. The files may be compressed (zipped).

Application deadline: 1 March 2018

For questions, please contact:
Fredrik Westerlund, Docent, Chemical Biology
Phone: +46 31 772 30 49

*** Chalmers declines to consider all offers of further announcement publishing or other types of support for the recruiting process in connection with this position. *** 

Chalmers University of Technology conducts research and education in engineering sciences, architecture, technology-related mathematical sciences, natural and nautical sciences, working in close collaboration with industry and society. The strategy for scientific excellence focuses on our eight Areas of Advance; Building Futures, Energy, Information & Communication Technology, Life Science, Materials Science, Nanoscience & Nanotechnology, Production and Transport. The aim is to make an active contribution to a sustainable future using the basic sciences as a foundation and innovation and entrepreneurship as the central driving forces. Chalmers has around 11,000 students and 3,000 employees. New knowledge and improved technology have characterised Chalmers since its foundation in 1829, completely in accordance with the will of William Chalmers and his motto: Avancez!