Ref. No. SU FV-0796-17
at The Department of Molecular Biosciences, The Wenner-Gren Institute (MBW) . Closing date: 24 April 2017.
MBW is building a new research animal facility at Stockholm University (SU) that is specially designed to address fundamental problems in biology that require the use of rodent models. The facility will be completed at the end of 2017, and will provide access to cutting-edge technologies. In particular, it will incorporate a state-of-the-art IntraVital Microscopy unit with imaging capabilities unique to Europe. Based on its potential, this unit at SU (IVMSU) has been awarded support as one of four nodes in the recently established Swedish National Infrastructure for Advanced Microscopy (NMI), an initiative funded by the Swedish Research Council (VR).
IVMSU is designed for "open access” to enable internal as well as external, non-SU, researchers to come and conduct a wide-range of high-resolution imaging studies requiring intravital microscopy to visualize molecular events at the cellular level in live animals and in exposed organs. Open-access is possible as the unit encompasses requisite quarantine and dedicated animal housing rooms for external researchers to bring their own animal models for study. IVMSU will also have an operating room for various surgery for instance implantation of specialized lenses required for certain IVM applications.
To ensure maximal flexibility, IVMSU will be equipped with two microscope stages, one upright and one inverted, a femtosecond pulsed multiphoton laser, generating light of one fixed wavelength and one tunable between 680 - 1300 nm. The latter enables non-invasive techniques, e.g., SHG and THG. The multiphoton laser light can be shifted between the two stages via a specific beam-splitter. For single-photon microscopy a range of laser lines will be available to allow excitation of the most commonly used fluorophores. Detectors and scanners will be of highest possible quality. Both stages will be built for observation of anesthetized rodents under temperature-controlled conditions, and for imaging diverse tissue preparations and cell cultures.
IVMSU's senior research engineer - a well-functioning IVM unit requires unique management skills and expertise. This position involves managing and facilitating the full-spectrum of experimental work carried out in the IVM unit. This will require establishing necessary routines and procedures to ensure the function of the unit and maintenance of equipment. A critical expectation is to ensure that all experiments have ethical approval and that image acquisition is carried out according to the strict internationally excepted guidelines governing the ethical treatment of animals. The duties involve assisting researchers with planning, execution and analysis of experiments. The senior research engineer should stay updated regarding advanced microscopy with particular focus on multiphoton microscopy.
A major responsibility is to communicate and disseminate information regarding IVMSU and to promote the use of the unit within the NMI. This will require communicating with representatives of the other NMI nodes, planning of and participation in NMI activities, including courses, workshops and roadshows. This will entail some travel within Sweden and abroad. The IVMSU senior research engineer is expected to play an active role in the long-term development of the unit.
A PhD in molecular biosciences/biomedicine/biophysics or equivalent is required. Detailed knowledge in advanced microscopy of biological material, minimally with 2-3 years of post-graduate experience working with wide-field, confocal and multiphoton microscopes is also a requisite. The candidate should have broad knowledge of specimen preparation, common fluorophores and other labelling techniques, and image analysis with ImageJ/Fiji and Imaris or similar programs. Experience of working with cells and research animals (rodents with documentation of completed courses in the handling of research animals) is desirable. The successful applicant lacking experience working with rodent models will be expected to complete training in surgery, anesthesiology and other specialized techniques relevant for IVM. Ultimately, it is expected that the senior research engineer develop the necessary theoretical and practical skills working with small animals required for intravital imaging. Good communication skills in English is essential, and preferable in Swedish as well.
The ideal candidate must have a strong background in advanced microscopy, including specimen preparation and data analysis. Experience with surgical methods and anesthesia on research animals is a clear merit. Teaching experience and skills, in classroom settings or in individual training sessions on microscope use, will also be considered. Other relevant expertise includes experience with core facility management and writing project-specific macros for imaging software.
Terms of employment
This is a full-time, indefinite-term position. Start date september 1, 2017 or as per agreement.
Stockholm University strives to be a workplace free from discrimination and with equal opportunities for all.
Further information about this position can be obtained by contacting the coordinator of the NMI node for intravital microscopy at SU, Professor Roger Karlsson, telephone +46-(0)8-16 4104, email@example.com, or the director of the SU animal facility Dr. Stina Tucker, telephone +46-(0)8-16 4014, firstname.lastname@example.org.
Anqi Lindblom-Ahlm (Saco-S) and Lisbeth Häggberg (Fackförbundet ST and Lärarförbundet), telephone: +46 8 16 20 00 (operator), and email@example.com (SEKO).
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Closing date: 24/04/2017
URL to this pagehttp://www.su.se/english/about/vacancies/vacancies-new-list?rmpage=job&rmjob=2895&rmlang=UK